丝颗粒的自我组装:机制和封装策略
Lauren E Eccles1, Andrea A Orozco2, Rebecca K Liwang3
1Chemical Engineering, University of Florida, Gainesville FL, 32611, USA.
概括
研究人员从未脱的Plodia interpunctella丝中开发出了新的丝颗粒. 这些丝颗粒有效地封装了各种分子,为各种应用提供了一个更快,更通用的生物材料平台.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物技术是生物技术.
背景情况:
- 丝蛋白是一种多功能生物聚合物,可用于制造纳米和微尺度颗粒.
- 来自丝的颗粒为各种应用提供稳定性,生物降解性和货物稳定性.
- 粒子特性取决于合成,蛋白质组成和载荷相互作用.
研究的目的:
- 用相分离和纳米沉来评估来自Plodia interpunctella丝的再生丝颗粒.
- 为了研究非脱的P. interpunctella丝对颗粒性能的影响,与脱的B. mori丝纤维素相比.
- 为了评估小分子的P. interpunctella丝颗粒的封装效率.
主要方法:
- 利用相位分离和纳米沉用于丝粒合成.
- 使用的非脱的Plodia interpunctella丝纤维.
- 具有特征的粒子形态,结晶性,大小,分散性和泽塔潜力.
- 评估了具有不同性质的小分子的封装.
主要成果:
- 来自未经脱P. interpunctella丝的颗粒显示出不同的特性 (形态,结晶性等). 与脱皮的B. mori丝纤维素颗粒相比.
- P. interpunctella丝颗粒对不同大小,疏水性和电荷的小分子表现出高的封装效率.
- 蛋白质组成和P. interpunctella丝纤维蛋白的结构图案影响了颗粒的形成和特征.
结论:
- 非脱P. interpunctella丝是一种可行的来源,用于创建具有可调节性质的基于丝的生物材料.
- 这些丝颗粒为扩大丝生物材料的功能应用提供了一个有希望的平台.
- 使用非脱丝丝纤维简化了再生过程,减少了加工时间.
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