皮里形输出神经元对认知和情感网络的空间分离
Chien-Fu F Chen1, Donald A Wilson2
1Graduate Institute of Life Sciences, College of Biomedical Sciences, National Defense Medical University, No. 161, Sec. 6, Minquan E. Rd, Neihu Dist, Taipei City 114201, Taiwan.
皮质皮质 (PCx) 通过它们的目标来组织输出神经元,而不是气味输入. 这种向底侧杏仁体和侧轨道前皮层投射的PCx神经元的空间组织支持处理气味的功能单元.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究 嗅觉系统研究
- 感官皮层组织组织 感官皮层组织
背景情况:
- 皮形皮质 (PCx) 是主要的嗅觉感官皮质.
- 与其他感觉皮层不同,PCx表现出广泛分布的气味唤起活动,缺乏特定刺激的空间组织.
- 有证据表明,基于输出神经元准,PCx空间组织可能存在.
研究的目的:
- 为了研究皮质皮质输出神经元的空间组织.
- 为了确定突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出.
- 确定PCx输出组织是否支持用于气味编码的功能单元.
主要方法:
- 使用双标签的逆行追踪技术.
- 将投射到BLA的PCx输出神经元的空间分布映射到BLA.
- 绘制了投射到LO皮质的PCx输出神经元的空间分布.
主要成果:
- 投射到BLA和LO皮层的PCx神经元表现出明显的空间分布.
- 在针对BLA和针对LO的PCx神经元之间观察到最小的重叠.
- 这支持一个模型,其中PCx输出,而不是输入,是空间组织的.
结论:
- 皮质皮质将输出神经元组织成特定目标人群.
- 这个组织,尽管随机的气味输入,建议功能单位的气味处理.
- PCx空间组织对于编码气味和指导行为至关重要.
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