通过口腔视频喉镜进行手术,用于从乳头甲状腺癌引起的下喉性形转移
Yuya Yokoyama1, Naoki Nishio1, Mai Sugiura1
1Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
JCEM case reports
|February 23, 2026
概括
这种罕见的病例显示,通过微创手术和向的BRAF/MEK疗法,成功治疗下喉形形甲状腺癌转移. 该方法保留了功能,并实现了持久的瘤控制,改善了患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 分子向疗法分子向疗法
背景情况:
- 乳头甲状腺癌很少会转移并经历形转变.
- 低喉转移呈现出像消化不良和呼吸道妥协这样的症状.
- 无塑性甲状腺癌是一种具有不良预后的侵袭性恶性瘤.
研究的目的:
- 报告一种罕见的低喉转移病例,该病例是由乳头甲状腺癌引起的形转变.
- 为了证明微创跨口腔手术与向治疗结合用于瘤控制的有效性.
- 突出一种功能维护的手术方法,与分子向抑制相结合.
主要方法:
- 通过活检诊断带有形甲状腺癌的下喉转移.
- 对局部瘤控制的微创透口视频喉腔镜手术.
- 基于基因检测 (BRAF V600E) 的BRAF/MEK抑制剂 (恩科拉费尼布和比尼米提尼布) 的术后向治疗.
主要成果:
- 通过口腔外科手术成功控制局部瘤,保持吞功能.
- 治疗后六个月没有疾病复发的证据.
- 气管切除术关闭和维持正常的吞和生活质量.
结论:
- 首先进行手术,功能维护的策略是有效的对下喉形形甲状腺癌转移.
- 早期分子向的BRAF/MEK抑制补充了手术管理.
- 这种综合方法可以实现持久的局部控制和保持喉功能.
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