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相关概念视频

Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

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Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Dosage Regimen: Individualization01:24

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
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在前列腺RT规划中导航变量:为以人为中心的CDS设计提供实时见解.

Meagan Foster1, Elizabeth Byrd1,2, Elizabeth Kwong1,2

  • 1Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, United States.

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概括
此摘要是机器生成的。

放射瘤学家通过个人解释和适应性策略适应前列腺放射治疗 (RT) 规划的变化. 这些发现有助于设计情境敏感的临床决策支持 (CDS) 工具.

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 人类因素工程 人类因素工程

背景情况:

  • 前列腺放射治疗 (RT) 规划中的临床变异性是一个已知的问题.
  • 了解这种变化背后的人类因素对于改善治疗一致性至关重要.
  • 人们对放射性瘤学家如何体验和适应驱动计划变化的因素知之甚少.

研究的目的:

  • 探索前列腺RT规划中的变化,作为以人为中心的设计挑战.
  • 通过获得对规划决策的实时洞察力,为临床决策支持 (CDS) 工具的设计提供信息.
  • 从辐射瘤学家的角度来看,识别导致变化的因素.

主要方法:

  • 在前列腺病例轮过程中,使用大声思考方法与五名放射瘤学家进行了观察会.
  • 观察后进行半结构面试,以收集深入的见解.
  • 在任务,技术和组织条件之间使用系统工程倡议患者安全 (SEIPS) 框架对变异性做出主题分析.

主要成果:

  • 前列腺RT规划的变化源于解剖学的模糊性,指导方针的解释和个人决策.
  • 放射性瘤学家采用适应性策略,包括依赖先前的经验和不确定性下的估计.
  • 在任务,技术和组织上下文中确定了导致变化的因素.

结论:

  • 前列腺放射治疗计划的变化受辐射瘤学家复杂的认知和适应过程的影响.
  • 需要环境敏感的CDS工具来支持临床推理,同时保持灵活性.
  • 以人为中心的设计方法对于开发辐射瘤学的有效决策支持至关重要.