多化学分析策略用于选原料和加工品之间的关键差异化合物Viticis fructus
Zijing Zhang1,2, Wenwen Li2, Ye Shang2
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300193 Tianjin, China.
ACS omega
|February 23, 2026
概括
这项研究使用先进的染色学和化学测量方法确定了原始和加工的葡萄酒果实 (Viticis fructus (VF)) 之间的关键化学差异. 这些发现有助于确保VF的质量和有效的临床使用.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 分析化学 分析化学
- 自然产品化学 自然产品化学
背景情况:
- 来自Vitex物种的Viticis fructus (VF) 是原始的和加工的.
- 了解加工引起的VF中的化学变化对于其应用和质量控制至关重要.
研究的目的:
- 为了确定原始和加工的Viticis fructus之间的关键差异性化合物.
- 建立可靠的分析策略,以区分原始和加工的VF.
主要方法:
- 高性能液体染色学二极管阵列探测器 (HPLC-DAD) 和超高性能液体染色学与四极飞行时间质谱学 (UHPLC-Q-TOF-MS) 结合使用化学指纹.
- 化学测量分析被用来选差异性化合物.
- 超高性能液态染色学与三重四极质谱学 (UHPLC-QQQ-MS/MS) 结合开发,用于针对性验证特定化合物.
主要成果:
- 成功地构建了原始和加工的VF的化学指纹.
- 最初在原始和加工VF之间确定了29种差异性化合物.
- 诸如咖啡酸,酸和丁酸等特定化合物被验证为区分VF形式的重要标记物.
结论:
- 处理过程显著改变了Viticis fructus的化学成分.
- 开发的分析策略为VF的质量评估和合理的临床应用提供了有价值的参考.
- 这项研究澄清了加工对VF成分的影响.
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