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在Grb2单体中依赖pH的形态变化揭示了氨酸的不同结合位点:对小分子药物发现的洞察力

Giovana Casteluci1,2, Raphael Vinicius Rodrigues Dias1,2, Jéssica Andrade Tedesco1,2

  • 1Department of Physics, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, 15054-000 São José do Rio Preto, SP Brazil.

ACS omega
|February 23, 2026
PubMed
概括

在pH值为7和8时,氨酸与单体Grb2 (适应蛋白) 的结合方式不同. 这种pH依赖的相互作用,受Grb2的影响.

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