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双功能的Sol-Gel抗菌材料,具有双相性八素释放,用于消毒和长期保护

Olga A Kamanina¹, Elizaveta A Lantsova¹, Evgeniya A Saverina^1,2

¹Tula State University, pr. Lenina 92, Tula 300012, Russia.

|February 23, 2026

概括

研究人员使用微生物模板和受控的消毒剂释放开发了环保的抗菌sol-gel材料. 这种可持续的方法为医疗和工业用途提供双重作用的微生物保护.

科学领域:

材料科学材料科学材料科学
生物技术是生物技术.
环境科学环境科学

背景情况:

创建抗菌sol-gel材料的传统方法通常依赖于有毒的表面活性剂.
需要可持续的,环保的替代品来生产具有可控释放性质的多孔材料.

研究的目的:

开发一种使用微生物模板合成抗菌sol-gel材料的新环保方法.
从这些新型材料中研究抗菌剂octenidine二化物的受控释放.
评估开发材料对植物病原体的抗菌疗效.

主要方法:

使用酵母和细菌细胞 (例如, * Paracoccus yeei *) 作为生物模板合成的sol-gel材料.
优化材料组成 (甲基三西/四西比) 和热处理 (800°C).
研究了octenidine二化的双相释放动力学,并评估了对*Rhodococcus fascians*的抗菌活性.

主要成果:

封装在50/50的甲基三氧化/四氧化sol-gel矩阵中的最佳材料是*Paracoccus yeei*.
八胺二化物表现出双相释放:快速的初始和持续的后续作用.
该材料表现出持续的抗菌活性,维持了25天的抑制区,特别是在纳入密封剂时.

结论:

整个微生物细胞作为有效的生物模板,用于创建具有可调节孔隙性的环保sol-gel矩阵.
开发的材料提供可控的双相消毒剂释放,提供即时和长期的微生物保护.
这些材料显示出各种应用的巨大潜力,包括医疗治疗和工业产品.

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