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多发性硬化症的功能神经症状:估计的患病率和相关的并发症

Luke C Collins^1,2,3, Michelle M Bagster^1,4, Lachlan Tamlin^2,5

¹Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide SA, Australia.

Neurology. Clinical practice

|February 23, 2026

概括

功能神经系统症状 (FNS) 影响15.1%的多发性硬化症患者 (PwMS),通常与女性性别,疲劳,认知问题,疼痛和偏头痛有关. 这些患者也显示出更高的精神病状况和急诊室访问率.

科学领域:

神经学神经学
精神病学是一个精神病学.

背景情况:

功能神经障碍 (FND) 呈现出结构损伤无法解释的不一致的神经症状.
多发性硬化症 (PwMS) 患者的功能神经症状 (FNS) 的研究是有限的.
在临床实践中,FNS可以显著导致残疾.

研究的目的:

在PwMS中估计FNS的流行率.
描述PwMS中与FNS相关的临床特征和并发症.

主要方法:

澳大利亚第三级多发性硬化症诊所 (2024) 成人PwMS的回顾性队列研究.
纳入标准:多发性硬化或临床/放射学隔离综合征诊断,年龄在18-64岁之间.
由神经科医生记录的FND定义的FNS,积极的检查迹象,持续的姿势感知头或功能认知障碍特征.

主要成果:

在15.1%的PwMS (62/411) 中发现了FNS.
患有FNS的PwMS更有可能是女性,并且经历了认知症状,功能性疲劳,慢性疼痛,偏头痛和多药性.
在患有FNS的PwMS中,观察到精神病并发症 (焦虑,抑郁,PTSD) 的更高患病率和急诊室使用率的增加.

结论:

在参加第三级诊所的PwMS中,FNS很普遍,与严重的医疗和精神病相关的并发症有关.
疲劳,认知症状,慢性疼痛和偏头痛是与PwMS中FNS相关的关键因素.
为了了解FNS在PwMS患者群体中的临床影响和管理,需要进一步的研究.

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