人类下皮层的一个精确的地图.
bioRxiv : the preprint server for biology
|February 23, 2026
概括
这项研究提供了一个高分辨率的人类大脑地图,详细介绍了皮层下结构. 这个基础资源增强了立体外科手术和皮层下神经成像研究.
科学领域:
- 神经科学是一个神经科学.
- 人体解剖学 解剖学 解剖学
- 医疗成像医学成像
背景情况:
- 目前的可变形大脑图谱缺乏用于皮层下临床干预和神经成像的分辨率.
- 精确的解剖学定义对于先进的大脑研究和手术规划至关重要.
研究的目的:
- 介绍一个高分辨率的人类大脑地图,详细的灰色和白色物质结构.
- 为皮层下脑成像和立体外科手术提供基础资源.
主要方法:
- 从体外MRI,组织学,纤维剖析和神经解剖学教科书中收集的数据.
- 95个灰色和白质结构和82个白质区域的手动细分.
- 在100微米的同位素分辨率下定义亚特拉斯,以准确地变形到个体解剖.
主要成果:
- 一个全面的人类大脑图谱,包含95个灰色/白质结构和82个白质区域.
- 高分辨率 (100微米) 地图精确地可根据个体受试者的大脑解剖学变形.
- 详细的解剖学定义的基底,乳腺体,亚乳腺体,中脑和小脑.
结论:
- 开发的地图集为皮层下研究提供了前所未有的解剖细节.
- 它作为对立体手术和神经成像的关键资源.
- 使下一代神经调节策略的进步成为可能.
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