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Updated: Feb 24, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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在C9orf72中重复扩展重新连接ALS中的3D染色质景观

Tatiana Ulloa Avila, Jingying Wang, Lydia Adams

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    在C9orf72中GGGGCC短串重复扩张会在肌缩侧面硬化症 (ALS) 中引起神经退行. 这项研究揭示了这些扩张通过创建新的染色质循环来破坏神经元基因组结构,从而导致基因失调.

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