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Updated: Feb 24, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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在siRNA指南链中的5'-酸有机基:在Argonaute 2中控制定和代谢稳定的结构功能关系

Theodore Carrigan-Broda, Luca F R Gebert, Samuel Hildebrand

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    新的5'-酸盐模仿剂通过增强Argonaute2结合来稳定RNA干扰的导向链. 这些修改后的模仿物抵御退化,提高了治疗潜力.

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