相关实验视频

Updated: Feb 24, 2026

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
07:06

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

2.1K

对PFAS-β-乳糖球蛋白结合机制的结构洞察力介导PFAS毒性

Shalja Verma, Anika Singh, Randhal S Ramirez Orozco

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    牛奶蛋白β-乳糖球蛋白在其脂肪酸结合部位结合有毒的per-和多基基物质 (PFAS). 这种由疏水力驱动的相互作用表明,β-乳糖球蛋白可能携带PFAS,可能导致神经毒性.

    更多相关视频

    The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions08:06

    The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

    Published on: February 1, 2018

    9.6K
    Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy09:30

    Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

    Published on: August 6, 2018

    9.9K

    相关概念视频

    Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

    Factors Affecting Protein-Drug Binding: Protein-Related Factors

    Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
    The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
    615
    Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

    Factors Affecting Protein-Drug Binding: Drug-Related Factors

    Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
    One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
    544
    Ligand Binding Sites02:40

    Ligand Binding Sites

    Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
    Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
    15.4K
    Ligand Binding and Linkage00:49

    Ligand Binding and Linkage

    Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
    5.7K
    Protein-Drug Binding: Mechanism and Kinetics01:16

    Protein-Drug Binding: Mechanism and Kinetics

    Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
    Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
    1.9K
    Factors Affecting Protein-Drug Binding: Drug Interactions01:23

    Factors Affecting Protein-Drug Binding: Drug Interactions

    Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
    Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
    660