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Updated: Feb 24, 2026

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
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在急性SIV感染和在ART启动的持久性OXPHOS期间,在CD4+T细胞中IFN驱动的脂质合成停止

Jinhee Kim, Anoop Ambikan, Jakob Harrison-Gleason

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    艾滋病毒/SIV感染改变CD4+T细胞代谢,通过干扰素反应关闭脂肪酸合成. 开始抗逆转录病毒疗法大致抑制新陈代谢,但线粒体功能仍然存在,提供潜在的治疗点.

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    Immunodeficiency Diseases01:25

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