Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Metabolism01:19

Regulation of Metabolism

11.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.8K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

1.4K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.4K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

1.0K
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
1.0K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.0K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.0K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.6K
Metabolic Rate01:25

Metabolic Rate

1.3K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

GLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.

Diabetes, obesity & metabolism·2026
Same author

RNA helicase associated with AU-rich elements (RHAU) regulates hepatic glucose homeostasis via a novel microRNA-150-Notch3-peroxisome proliferator-activated receptor γ pathway.

International journal of biological macromolecules·2026
Same author

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity.

Nature·2026
Same author

Hypocalcemia in Dialysis Is Not Associated with Increased Mortality: Evidence from a Population-Based Cohort.

Nutrients·2026
Same author

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin-1 to Restore Vascular Homeostasis After Ischemic Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Whole-Embryo 3D Quantification Reveals Conserved Topological Design and Scaling of Germ Layers in Xenopus.

bioRxiv : the preprint server for biology·2026
Same journal

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

bioRxiv : the preprint server for biology·2026
Same journal

M1C IS NECESSARY FOR DARAXONRASIB RESISTANCE OF NSCLC KRAS(G12C) MUTANT CELLS.

bioRxiv : the preprint server for biology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Feb 24, 2026

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
10:45

Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

Published on: December 19, 2012

20.8K

一个预视神经电路调节代谢灵活性

Julian M Roessler, Matthew Alkire, Nathan Nigrin

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括
    此摘要是机器生成的。

    大脑是大脑的大脑.

    更多相关视频

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    725
    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
    11:45

    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

    Published on: November 14, 2013

    12.7K

    相关实验视频

    Last Updated: Feb 24, 2026

    Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
    10:45

    Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex

    Published on: December 19, 2012

    20.8K
    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    725
    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
    11:45

    Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

    Published on: November 14, 2013

    12.7K

    科学领域:

    • 神经科学是一个神经科学.
    • 代谢过程中的代谢.
    • 内分泌学 在内分泌学.

    背景情况:

    • 代谢灵活性对于生存至关重要,使动物能够适应燃料使用和环境变化.
    • 虽然荷尔蒙调节代谢灵活性,但人们对中枢神经系统的作用不太了解.
    • 前中前视区域 (avPOA) 含有参与和代谢调节的神经元.

    研究的目的:

    • 研究如何激活avPOA中的特定神经元影响代谢燃料的选择和利用.
    • 确定这些神经元控制外围组织中葡萄糖和脂肪酸代谢的机制.
    • 探索中枢神经系统在协调全身代谢灵活性方面的作用.

    主要方法:

    • 在小鼠中激活调节的谷氨基基Adcyap1+神经元 (avPOA Vglut2/PACAP) 的急性激活.
    • 测量全身燃料利用率 (葡萄糖与脂肪酸对比).
    • 评估骨肌肉中的葡萄糖耐受性和胰岛素敏感性.
    • 调查皮质在调解代谢转变中的作用.

    主要成果:

    • 激活avPOA Vglut2/PACAP神经元迅速将燃料使用量从葡萄糖转移到脂肪酸.
    • 这种转变与骨肌肉中葡萄糖利用率降低和选择性胰岛素抵抗有关.
    • 代谢重编程部分由皮质调节,独立于直接肌肉内置.
    • 沉默这些神经元改善了葡萄糖耐受性,表明双向控制.

    结论:

    • 从avPOA到骨肌肉的新的神经通路动态调节葡萄糖利用率和代谢灵活性.
    • 中枢神经系统在协调燃料选择和代谢适应方面发挥着至关重要的作用.
    • 针对这种途径可以为代谢疾病管理提供新的策略.