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Updated: Feb 24, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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蛋白质稳定维持T细胞分化潜力和瘤透淋巴细胞功能

Nicole E Scharping, Xuezhen Ge, Maria Inês Matias

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    瘤透淋巴细胞 (TIL) 可能会耗尽,阻碍抗瘤免疫力. 在临床前模型中,通过重新引入E3泛素酶来恢复蛋白质稳定,改善了TIL功能并增强了癌症免疫治疗结果.

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