5岁以下儿童功能网络的共同性和可变性
bioRxiv : the preprint server for biology
|February 23, 2026
概括
个性化的大脑网络,包括语言区域,在五岁之前在幼儿中出现. 这种早期的功能性大脑架构是稳定的,与认知发展有关,为典型的发展提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 人类的认知依赖于功能性大脑网络,但它们的早期发育轨迹和个体差异尚未得到充分理解.
- 传统的方法平均数据跨参与者可以掩盖关键的特定年龄组织和个体变异性,特别是在发育大脑区域.
研究的目的:
- 从休息状态的fMRI数据开发适合年龄的功能参考来估计幼儿的个性化大脑网络.
- 研究早期儿童个性化的功能性大脑网络架构的出现和稳定性.
- 探索早期大脑网络组织和认知能力之间的关系.
主要方法:
- 开发了一种新的适合年龄的功能参考,以捕捉幼儿的共同结构,同时保持个体变异性.
- 利用休息状态功能磁共振成像 (fMRI) 数据从8至60个月大的儿童队伍.
- 分析了网络地形,纵向稳定性,网络内连接性和语言横向化,与语言能力相关.
主要成果:
- 个性化的功能性大脑网络,包括更细致的细分和新兴的语言横向化,在8个月大的儿童中被发现,早在5岁之前.
- 网络组织表现出纵向稳定性,与关联皮层相比,在感官区域观察到的一致性更大.
- 更强大的网络内连接,当被个性化地形定义时,解释了与年龄相关的差异,并将左侧化语言网络与年龄规范化语言能力联系起来.
结论:
- 行为相关的功能性大脑网络在发育过程中出现的时间比以前认为的要早得多.
- 个性化网络分析为研究早期大脑发育及其与认知的联系提供了更敏感的方法.
- 这些发现为研究典型的早期神经发育和识别潜在的早期生物标志物奠定了基础.
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