准胰前端通路,以减少压力引起的认知刚性
bioRxiv : the preprint server for biology
|February 23, 2026
概括
前部岛内皮层 (aIC) 到中部前额叶皮层 (mPFC) 的电路调节了认知灵活性. 这条路径的路径.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 行为神经科学 行为神经科学
背景情况:
- 前岛皮层 (aIC) 对突出网络和认知灵活性至关重要.
- 认知刚性是压力相关疾病的标志,但其神经支尚未完全理解.
- 对于aIC在认知刚性中的因果作用仍然不清楚.
研究的目的:
- 研究前岛皮层 (aIC) 投射到中间前额叶皮层 (mPFC) 在认知灵活性中的因果作用.
- 阐明压力如何影响aIC功能和认知灵活性.
- 为了确定aIC→mPFC电路作为潜在的治疗目标认知刚性.
主要方法:
- 在小鼠中注意力设置转移任务 (AST).
- 对aIC→mPFC投影的光遗传学操纵.
- 在认知任务期间的体内神经活动记录.
- 压力诱导范式 压力诱导范式
主要成果:
- 投射到mPFC的aIC神经元在不正确的试验后表现出高度活动,信号突出.
- 对aIC→mPFC预测的光遗传学干扰损害了适应性决策和AST性能.
- 压力破坏了aIC活动的结果依赖性,并影响了设置转移.
- 在错误后加强aIC→mPFC活动可以挽救受压力小鼠的认知灵活性.
结论:
- aIC→mPFC电路对于将试验结果与适应性决策联系起来至关重要.
- 这一途径在保持认知灵活性方面发挥着关键作用.
- aIC→mPFC电路代表了应激诱导的认知刚性的有希望的治疗标.
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