相关实验视频

Updated: Jul 1, 2026

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

21.0K

在C9orf72缺乏的小鼠中,输入内 (G 4 C 2) 149的输送产生了轻度运动功能障碍和ALS/FTD病理特征

Katelyn A Russell, Amelia A Shahrabi, Suleyman C Akerman

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    一种新的病毒载体方法通过准C9orf72基因重复扩张,有效地模拟小鼠的肌缩性侧面硬化症 (ALS) 和前性痴呆症 (FTD). 这种方法揭示了关键的脊髓病态和轻微的运动缺陷,为疾病机制提供了洞察力.

    更多相关视频

    Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells08:53

    Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

    Published on: May 16, 2017

    9.2K
    Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis08:59

    Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

    Published on: July 16, 2021

    3.2K

    相关概念视频

    Huntington Disease l: Introduction01:21

    Huntington Disease l: Introduction

    Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...