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Updated: Feb 24, 2026

08:48
A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
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伴随性艾滋病毒和可卡因使用 恶化剂 加快大脑衰老
bioRxiv : the preprint server for biology
|February 23, 2026
概括
同病性艾滋病毒和可卡因使用加快大脑衰老,增加认知障碍风险. 这个大脑年龄差距突出了特定的网络变化和潜在的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染和可卡因使用 (CU) 独立地与认知缺陷和大脑异常有关.
- 艾滋病毒和CU对大脑衰老和认知功能的综合影响仍然不完全理解.
研究的目的:
- 为了研究伴随性艾滋病毒和CU和加速大脑衰老之间的关系.
- 检查大脑年龄差距 (BAG) 与HIV和/或CU患者的神经认知障碍 (NCI) 的关系.
- 为了确定与并发性艾滋病毒和CU相关的特定大脑结构变化.
主要方法:
- 使用高斯过程回归对人类连接体项目-衰老 (HCP-A) 数据训练了一种基于形态学的大脑年龄模型.
- 将模型应用于具有不同HIV/CU负担的独立队列 (HIV-/CU-,一种疾病,HIV+/CU+).
- 分析了与并发症负担和NCI相关的脑年龄差距 (BAG),控制共变量;用于网络层面分析的SHapley添加式扩展 (SHAP).
主要成果:
- 观察到对BAG的并发症负担的剂量依赖效应,HIV+/CU+组表现出最大的BAG.
- 增加的BAG与更高的NCI可能性显著相关.
- BAG部分调解了并发症负担和NCI之间的关联,在双重疾病组中效果更强.
结论:
- 并发性HIV和CU与加速的结构性大脑衰老有关.
- 大脑年龄差距可以作为大脑变化的生物标志物,将伴随性HIV/CU与认知障碍联系起来.
- 确定BAG的网络特异性贡献可以为携带HIV和CU的个人提供有针对性的干预措施.
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