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Updated: Feb 24, 2026

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TRIM32-UBQLN2-p62轴通过穿凝结物促进了TDP-43的纳入形成和粉样蛋白聚合

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    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    E3无素酶TRIM32形成蛋白质凝聚物,捕获和聚合像TDP-43这样的蛋白质,导致神经退行性疾病,如ALS和FTLD.

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