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Updated: Feb 24, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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对于强大的PROTACs来说,亚静脉测量降解是不可或缺的:对于不可逆转的共价BTK降解剂的案例研究

Ran Cheng, Hanfeng Lin, Xin Yu

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    化蛋白解向的嵌合体 (PROTACs) 可以有效地降解像布鲁顿氨酸激酶 (BTK) 这样的向蛋白质. 这项研究表明,不可逆转的结合驱动了强有力的和选择性的降解,挑战了关于PROTAC机制的先前假设.

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