相关实验视频
Updated: Feb 24, 2026

10:36
Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
15.1K
不同的凝聚物在压力过程中调整了转录反应
bioRxiv : the preprint server for biology
|February 23, 2026
概括
热冲击因子1 (HSF1) 在压力过程中形成核凝结物. 这些组件可以根据压力类型激活或抑制转录,影响细胞反应和疾病.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 在哺乳动物应激反应过程中,没有核膜的隔间会动态重组.
- 压力诱导的冷凝物形成的机制及其在转录调节中的作用尚未得到充分理解.
研究的目的:
- 研究在各种应力条件下,热冲击因子1 (HSF1) 如何形成冷凝物.
- 为了确定HSF1凝析物形成的上下文依赖的转录结果.
主要方法:
- 在不同压力条件下 (热冲击,环境,化疗) 研究HSF1凝析物形成和动态.
- 分析了翻译后修饰 (PTMs),三元化,DNA结合和亚凝聚力学.
- 评估HSF1相关位置的基因组占用率和转录输出.
主要成果:
- HSF1形成了取决于上下文的凝聚物,具有不同的转录结果.
- 热冲击会诱导正规的HSF1激活和转录枢纽组合.
- 其他压力导致冷凝物形成停滞,动力学减少和转录活动受损.
结论:
- 压力诱导的转录因子凝聚物介导保守反应,但在病理性侮辱期间可以被禁用.
- HSF1凝聚物失活解释了退行性疾病和有毒暴露中的转录功能障碍.
- HSF1的无序区域在调节凝结物形成和活动方面发挥着作用.
相关概念视频
Other Stress Responses in Bacteria
457
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
457
Stress Response System
961
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
961
Responses to Salt Stress
14.8K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.8K
Transcription
157.5K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
157.5K
Transcription
34.0K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
34.0K
Stringent Response in E. coli
414
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
414

