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Updated: Jun 9, 2026

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HAPI细胞是与SIM-A9相关的小鼠微质细胞,可用于微质免疫代谢的体外建模

Ryan P Mayers, Sausan M Jaber, Nicolas Verhoeven

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    概括

    高度激进的增殖不朽化 (HAPI) 细胞是小鼠,而不是老鼠的微质细胞. 尽管存在错误的鉴定,但HAPI细胞保留了类似于微质的特性,这对体外免疫代谢研究有价值.

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    Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...