用益生菌注入的活性炭/酸微粒:一种新的消毒策略
1Laboratory Medicine Department, Faculty of Applied Medical Sciences, Alaqiq, Al-Baha, Saudi Arabia.
PeerJ
|February 23, 2026
概括
一种新的益生菌注入微珠配方 (PIMD) 提供快速,广泛的消毒和长期的表面保护. 这种可持续的方法减少了对抗生素和化学消毒剂的依赖,以提高安全性.
科学领域:
- 生物技术和材料科学 生物技术和材料科学
- 微生物学与环境科学 微生物学与环境科学
背景情况:
- 医疗保健和食品设施中的高风险表面需要有效的,无毒的消毒策略.
- 现有的消毒剂往往会给环境带来风险或导致抗菌素耐药性.
- 基于益生菌的解决方案为病原体控制提供了一个可持续的替代方案.
研究的目的:
- 开发和评估用于表面消毒的注入益生菌的活性炭/酸微粒 (PIMD).
- 评估PIMD的快速病原体抑制和持续的竞争排除的双重机制.
- 研究PIMD对一系列致病菌株的疗效,包括抗生素耐药菌株.
主要方法:
- 使用活性炭和氧酸盐封装12种益生菌菌株的工程微珠.
- 综合生态建模 (竞争性排斥,洛特卡-沃尔特拉动态) 与抗菌检测.
- 在不钢,切割板和培养板上对43种病原菌株的PIMD有效性进行了评估.
主要成果:
- 在365天的时间里,PIMD在-20°C和4°C的温度下表现出物理稳定性和保存的益生菌活力.
- 在1小时内实现≥99.9%的病原体负载减少,并保持保护性生物膜≥21天.
- 对43种病原体表现出显著的抑制区,对34.9%的菌株产生杀菌作用.
结论:
- PIMD提供了一种双重行动策略,用于快速消毒和长期微生物平衡.
- 该配方减少了对抗生素和化学消毒剂的依赖,提高了表面的安全性.
- 对于在医疗保健,食品安全等领域的多样化应用,PIMD显得有前途.
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