人体血清中PFAS度的增加与血脂水平升高相关
Ashlee T Falls1, Anna K Boatman1, Jack P Ryan1
1Department of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.
高和多醇基物质 (PFAS) 暴露与特定脂质水平的增加有关,包括甘油三和酸乙醇胺. 这些变化表明高暴露个体的细胞膜和能量储存的改变.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的合成化学物质,在全球超过99%的人群中发现.
- 现有的研究将某些PFAS与胆固醇升高联系起来,但特定的脂质物种变化仍未得到充分研究.
- 高 PFAS 暴露与失脂症,甲状腺功能障碍和癌症的风险有关.
研究的目的:
- 为了研究血清中高度的甲酸和多甲基物质 (PFAS) 与特定的脂类物种之间的关联.
- 为了探索因高 PFAS 暴露而导致的脂质代谢的潜在机械变化.
- 评估通过饮用水和职业来源显著暴露于PFAS的个体的脂质学变化.
主要方法:
- 分析了49名参与者饮用水暴露率高的PFAS和29名职业暴露的消防员的血清样本.
- 参与者根据7个PFAS (Σ7 PFAS) 的血清度总和进行分组.
- 对387种检测到的脂质物种进行了脂质组分析,对S7 PFAS≥20 ng mL-1.1的参与者进行了统计比较.
主要成果:
- 在387个检测到的脂质中,有24个在参与者中显著升高,具有高Σ7 PFAS度 (≥20 ng mL-1).
- 甘油三和酸乙醇胺占这些升高脂质的62.5%,表明对能量储存和细胞膜的影响.
- 在饮用水队列中仅限女性子组的分析验证了这些发现.
结论:
- 血清中度增加的和多基基物质 (PFAS) 与高的特定脂类相关.
- 这些发现表明,PFAS暴露会改变脂质代谢,影响细胞膜结构和能量储存途径.
- 需要进一步的研究,以了解PFAS诱导的脂质体变化对健康的全部影响.
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