病例报告:异常持续升高的托罗邦素I-系统性硬化症被急性心肌梗塞掩盖
Lixia Zhang1, Shuqi Li2, Jinglei Niu1
1Heart Center, The First Hospital of Lanzhou University, Lanzhou, China.
Frontiers in immunology
|February 23, 2026
概括
本病例报告详细介绍了系统性硬化症 (SSc) 患者的心肌梗塞 (MI) 的情况. 早期诊断和量身定制的治疗导致了患者的显著改善,为管理这种罕见的并发症提供了洞察力.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 心肌梗塞 (MI) 是全球主要的死亡原因,源于冠状动脉封闭.
- 系统性硬化症 (SSc) 是一种罕见的自身免疫性疾病,导致纤维化和血管问题,与高死亡率有关.
- 肌痛性心脏病和SSc的同时发生带来了诊断和治疗方面的挑战.
研究的目的:
- 在患有全身性硬化症 (SSc) 的患者中报告一种罕见的心肌梗塞 (MI) 病例.
- 记录这种复杂的并发症的诊断和治疗途径.
- 在SSc.的背景下提供有关管理MI的见解.
主要方法:
- 一个55岁的男性患有急性下等心脏病发作的病例报告.
- 穿皮冠状动脉干预 (PCI),其次是持续高心脏托罗邦素I (cTnI).
- 诊断的SSc通过遗传病学活检证实再入院后残留的血管病变.
主要成果:
- 这位患者出现了急性心脏病发作,最初用PCI治疗,但没有显示cTnI下降趋势.
- 持续高的cTnI和残留的血管病变导致SSc诊断.
- 在治疗后3个月的随访后,患者的病情明显改善.
结论:
- 这一案例凸显了在心脏病发作和未解释的心脏酶升高的患者中考虑SSc的重要性.
- 这种罕见的并发症的有效管理可以带来有利的患者结果.
- 这些发现可能会为未来的MI与SSc结合的诊断和临床策略提供信息.
更多相关视频
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
9.7K
10:12A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
17.2K
相关概念视频
01:30Acute Coronary Syndrome I: Introduction
1.2K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.2K
01:30Acute Coronary Syndrome III: Diagnostic Studies
321
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
321
01:27Myocarditis II: Clinical Features and Diagnostic Tests
366
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
366
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
553
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
553
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
497
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
497
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
632
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
632