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在IgA病中Nefecon的有效性和安全性:现实世界的临床实践

Zihan Zhai¹, Zhibin Huang¹, Liuwei Wang¹

¹Department of Nephropathy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in immunology

|February 23, 2026

概括

向释放布迪索尼德 (Nefecon) 在现实环境中显著减少IgA脏病 (IgAN) 患者的蛋白尿症. 这种治疗还可以保持功能,即使在高危子组.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

IgA病 (IgAN) 是一种慢性病,其特征是免疫失调.
向释放布德索尼德 (Nefecon) 向肠关联淋巴组织 (GALT),以减少缺银河糖的IgA1 (Gd-IgA1) 生产.
以前的试验 (NEFIGAN,NefIgArd) 证明了Nefecon在减少蛋白尿和减缓慢性病 (CKD) 进展方面的有效性,但实际数据有限.

研究的目的:

为了评估Nefecon在IGAN患者中的实际有效性.
为了评估蛋白尿的变化和估计的淋巴球过率 (eGFR) 在接受Nefecon治疗的Igan患者.
分析Nefecon在特定亚组的疗效,包括那些同时接受免疫抑制疗法和具有不同基线功能的人.

主要方法:

一项追溯的队列研究,对60名Igan患者进行了至少6个月的Nefecon (16毫克/天) 治疗.
在治疗开始后4个月和6个月评估蛋白尿和eGFR变化.
基于并发免疫抑制疗法,基线蛋白尿和基线eGFR的亚组分析.

主要成果:

在4个月 (31.9%) 和6个月 (43.5%) (p < 0.001) 观察到显著的蛋白尿减少.
在整个研究期间,估计的淋巴膜过率 (eGFR) 保持稳定.
与单独治疗 (35.8%) 相比,接受Nefecon和其他免疫抑制剂的患者在6个月后显示出较大的蛋白尿减少 (48.1%).
在基线eGFR<35mL/min/1.73m2的患者中,没有恶化功能 (p=0.002) 的情况下,观察到显著的蛋白尿减少 (38.9%).
尼菲康的耐受性很好,但有轻微的不良反应.

结论:

在Igan患者中,Nefecon在减少蛋白尿和保持功能方面展示了现实世界的有效性.
这些发现支持Nefecon作为高风险IGAN患者的实用治疗选择,扩展了之前的试验结果.
与免疫抑制剂的联合治疗可能会带来额外的益处,需要进一步调查.

关键词:

慢性结核病的进展情况欧洲农业基金会 (EGFR) 是一个基金.在IgA脏病发作中,IgA脏病发作尼菲康尼 (NEFECON) 是一个国家.蛋白质尿症是一种蛋白质尿症.

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