与牛皮相比,结性脊髓炎中炎症性肠病的风险增加
Zhen He1, Yi-Nan Zhang1, James Cheng-Chung Wei2,3,4
1Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in immunology
|February 23, 2026
概括
与牛皮 (PSO) 和牛皮性关节炎 (PsA) 相比,性脊柱炎 (AS) 显著增加了炎症性肠病 (IBD) 的风险,包括克罗恩病和性结肠炎. 在这些疾病中,AS患者面临的IBD负担最高.
科学领域:
- 风湿病学和胃肠道学
- 免疫皮肤学和免疫学
- 流行病学和生物统计学
背景情况:
- 化脊柱炎 (AS) 和牛皮性关节炎 (PsA) 分享免疫失调路径.
- 在AS,PsA和牛皮 (PSO) 中发展炎症性肠病 (IBD) 亚型的比较风险尚未确定.
研究的目的:
- 量化和比较AS,PSO和PsA队列中IBD发展的风险梯度.
- 为了确定与每个疾病相关的IBD相对风险.
主要方法:
- 从2005-2023年使用电子健康记录的回顾性队列研究.
- 倾向性得分匹配 (PSM) 来控制混变量.
- 考克斯的比例危险模型和日志等级测试来评估IBD风险.
主要成果:
- 与PSO相比,AS的确定的IBD (HR=2.96),克罗恩病 (HR=3.38),性结肠炎 (HR=2.43) 和不确定的结肠炎 (HR=2.45) 的风险明显更高.
- 与普通人群相比,AS为确定的IBD (HR=4.22) 赋予了最高的独立风险,PSA (HR=1.52) 和PSO (HR=1.37).
- 亚氏硬化症的确切IBD风险比PSA高2.60倍.
结论:
- 结性脊柱炎是与IBD最强烈相关的表型.
- 与牛皮患者相比,AS患者患克罗恩病,性结肠炎和不确定的结肠炎的风险明显增加.
- 与牛皮关节炎或一般人群相比,AS携带的确定的IBD负担更大.
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