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混合结缔组织疾病患者视网膜微血管密度降低:关于衰老,功能和补充系统之间的相互作用的探索性试点研究

Paola Triggianese¹, Eugenio Capparelli², Arianna D'Antonio²

¹Geriatric and Nutrition Unit, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.

Frontiers in immunology

|February 23, 2026

概括

混合结合组织疾病 (MCTD) 患者的视网膜血管密度降低,可通过OCT-A检测. 这些微血管变化与疾病持续时间,功能和补充水平相关,表明OCT-A.

科学领域:

眼科医生眼科眼科
类风湿病学类风湿病学
免疫学免疫学免疫学

背景情况:

混合结缔组织疾病 (MCTD) 是一种自身免疫性疾病,具有狼,硬皮病和肌炎的重叠症状,通常以抗U1-RNP抗体为标志.
虽然在其他连接组织疾病中已知有视网膜微血管变化,但特定于MCTD患者的数据有限.

研究的目的:

用光学相干断层扫描血管学 (OCT-A) 调查混合结合组织疾病 (MCTD) 患者的亚临床视网膜微血管异常.
探索视网膜血管变化和临床参数 (如疾病持续时间,功能和MCTD中的补充水平) 之间的潜在相关性.

主要方法:

一项涉及20名MCTD患者和20名年龄/性别匹配的健康对照 (HC) 的横截面试验研究.
光学连贯性断层扫描血管造影 (OCT-A) 用于评估视网膜血管密度 (VD) 和状血管区域 (FAZ).
在MCTD患者身上进行了指甲视频毛囊显微镜 (NVC),以评估微血管病变模式.

主要成果:

与HC相比,MCTD患者表现出明显减少的表面和深视网膜VD.
深视网膜VD与疾病持续时间相反相关,并在MCTD患者中与估计的淋巴细胞过率 (eGFR) 呈正相关.
在MCTD患者中,表面的副体静脉疾病与C3补充水平呈正相关性.
在60%的MCTD患者中,NVC发现了微血管病变,但这些发现与OCT-A结果没有相关性.

结论:

在MCTD患者中,亚临床视网膜微血管异常可以通过OCT-A检测到.
在MCTD中视网膜血管变化可能与疾病持续时间,功能和补充水平有关.
OCT-A显示了其作为评估MCTD血管参与的有价值工具的潜力.

关键词:

老化的老化衰老的老化互补系统是互补的系统.混合结合组织疾病混合结合组织疾病指甲折叠视频毛发显微镜光学连贯断层扫描血管造影 (OCT-A)功能功能功能视网膜血管系统的血管结构

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