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相关概念视频

Bile01:19

Bile

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Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
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Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
651
Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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相关实验视频

Updated: Feb 24, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

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在病理生理学中的胆汁酸的类免疫调节.

Bo-Shen Lin1, Min-Yue Yin1, Si-An Xie1

  • 1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.

Frontiers in immunology
|February 23, 2026
PubMed
概括

胆汁酸 (BAs) 是影响宿主新陈代谢,肠道微生物群和免疫力的关键信号分子. 本综述探讨了BA如何调节免疫细胞并影响疾病,强调了针对BA途径的治疗策略.

关键词:
自身免疫性疾病 自身免疫性疾病胆汁酸 胆汁酸 胆汁酸癌症 癌症 癌症 癌症 癌症我们的肠道微生物群.免疫力是一种免疫力.

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Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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相关实验视频

Last Updated: Feb 24, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

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Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

517

科学领域:

  • 免疫学 免疫学 免疫学
  • 代谢过程中的代谢.
  • 微生物学 微生物学

背景情况:

  • 胆酸 (BAs) 的作用已经超越了消化作用,成为关键的信号分子.
  • 维生素A与宿主新陈代谢,肠道微生物群和免疫系统功能相结合.
  • 失调的BA信号与各种疾病有关,包括炎症,自身免疫,代谢和恶性疾病.

研究的目的:

  • 审查胆汁酸在调节先天性和适应性免疫中的多方面的作用.
  • 通过检查胆酸通过特定受体调节免疫细胞活动的机制.
  • 讨论胆酸信号在不同组织和疾病背景中的影响.

主要方法:

  • 关于胆酸信号传递和免疫功能研究的文献综述.
  • 分析特定受体 (FXR,TGR5,VDR,RORs) 在调解BA对免疫细胞影响中的作用.
  • 检查组织特异性BA信号及其对免疫平衡的影响.

主要成果:

  • 胆酸调节关键免疫细胞的活性,包括巨细胞,树突细胞,T细胞,NK细胞和NKT细胞.
  • 像FXR,TGR5,VDR和ROR这样的特定受体调解BA的各种免疫调节功能.
  • 组织特异性的BA信号影响肠道,肝脏,中枢神经系统和瘤微环境中的免疫平衡.

结论:

  • 胆酸是免疫平衡的关键调节剂,在健康和疾病中起着重要作用.
  • 准胆酸通路为免疫相关疾病提供了有前途的治疗策略.
  • 对胆汁酸与免疫交叉的进一步研究可以促进精密免疫疗法和基于微生物的干预.