在病理生理学中的胆汁酸的类免疫调节
Bo-Shen Lin1, Min-Yue Yin1, Si-An Xie1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Frontiers in immunology
|February 23, 2026
概括
胆汁酸 (BAs) 是影响宿主新陈代谢,肠道微生物群和免疫力的关键信号分子. 本综述探讨了BA如何调节免疫细胞并影响疾病,强调了针对BA途径的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 微生物学 微生物学
背景情况:
- 胆酸 (BAs) 的作用已经超越了消化作用,成为关键的信号分子.
- 维生素A与宿主新陈代谢,肠道微生物群和免疫系统功能相结合.
- 失调的BA信号与各种疾病有关,包括炎症,自身免疫,代谢和恶性疾病.
研究的目的:
- 审查胆汁酸在调节先天性和适应性免疫中的多方面的作用.
- 通过检查胆酸通过特定受体调节免疫细胞活动的机制.
- 讨论胆酸信号在不同组织和疾病背景中的影响.
主要方法:
- 关于胆酸信号传递和免疫功能研究的文献综述.
- 分析特定受体 (FXR,TGR5,VDR,RORs) 在调解BA对免疫细胞影响中的作用.
- 检查组织特异性BA信号及其对免疫平衡的影响.
主要成果:
- 胆酸调节关键免疫细胞的活性,包括巨细胞,树突细胞,T细胞,NK细胞和NKT细胞.
- 像FXR,TGR5,VDR和ROR这样的特定受体调解BA的各种免疫调节功能.
- 组织特异性的BA信号影响肠道,肝脏,中枢神经系统和瘤微环境中的免疫平衡.
结论:
- 胆酸是免疫平衡的关键调节剂,在健康和疾病中起着重要作用.
- 准胆酸通路为免疫相关疾病提供了有前途的治疗策略.
- 对胆汁酸与免疫交叉的进一步研究可以促进精密免疫疗法和基于微生物的干预.
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