SARS-CoV-2感染与循环IL-32水平长期增加的关联
Lorenzo Miano1, Elena Sinopoli2, Alessandro Cherubini2
1Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy.
Frontiers in immunology
|February 23, 2026
概括
在COVID-19大流行期间,以及在患有严重COVID-19的患者中,人体中interleukin-32 (IL-32) 水平增加. 升高的IL-32持续在出院后长达一年,表明长期炎症的可能性.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物标志物研究 生物标志物研究
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染具有广泛的临床谱,从无症状病例到严重的超炎症和免疫障碍.
- 介素-32 (IL-32) 是一种已知的促炎性细胞因子,涉及病毒感染和慢性肺部疾病.
研究的目的:
- 调查SARS-CoV-2流行病和严重的COVID-19对循环IL-32水平的影响.
- 评估IL-32作为COVID-19严重程度和长期后果的潜在生物标志物.
主要方法:
- 一项观察性回顾性生物标志物研究分析了949名健康献血者 (流行病前和流行病时代) 和212名住院的严重COVID-19患者.
- 使用酶相关免疫吸收测试 (ELISA) 量化IL-32水平.
主要成果:
- 与大流行前的捐赠者相比,大流行时期的捐赠者显示IL-32水平显著增加 (p<0.0001).
- 严重的COVID-19患者与未暴露的对照人群相比呈现高IL-32 (p=0.016),在第一波期间水平更高.
- IL-32与皮质类固醇使用和年龄相关,反向与中性粒细胞与淋巴细胞的比率相关,但与IL-6或内皮功能障碍标志物无关. 排放后一年的水平保持稳定.
结论:
- 在COVID-19感染后,IL-32水平上升,特别是在早期大流行浪潮期间的严重病例中.
- 离院后长达一年的IL-32持续升高表明正在进行的炎症,并强调其作为长期COVID-19并发症生物标志物的潜力.
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