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腰部交感溶解减轻了耐化学治疗诱导的下肢周围神经病变:一个前性的,现实世界的研究
Jiaojiao Suo1, Fang Zhang2, Bifa Fan3
1Department of Pain Rehabilitation and Palliative Medicine, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, People's Republic of China.
Journal of pain research
|February 23, 2026
概括
CT引导的腰部同情解剖显示出治疗化疗诱导的周围神经病变 (CIPN) 症状如疼痛和麻木的前景. 这种微创手术可以为耐火性CIPN患者提供显著的缓解,副作用很少.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 干预性放射学 干预性放射学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 由于有效治疗方法有限而构成重大挑战.
- 耐火性CIPN显著影响患者的生活质量,需要新的治疗方法.
研究的目的:
- 评估CT引导的腰部交友解剖的疗效和安全性,以缓解耐火性CIPN患者的症状.
- 评估这种微创手术对下肢疼痛,麻木,感冒和运动障碍的影响.
主要方法:
- 一个单臂,前性观察性研究,涉及25名耐火性CIPN.患者.
- 进行CT引导的腰部同情分析,并在治疗后的多个时间点使用数值评分表 (NRS) 评估症状严重程度.
- 治疗反应被定义为NRS得分减少≥30%,并仔细记录不良反应.
主要成果:
- 在所有随访期间 (3天,1个月,3个月) 观察到NRS疼痛,麻木,感冒和动力障碍的得分显著降低.
- 具体症状的改善包括疼痛 (高达61.1%),麻木 (高达24.0%),感冒 (高达71.4%) 和不运动 (高达57.1%).
- 整体症状减轻显著,达到68%在3天,64%在1个月,60%在3个月,没有临床显著的不良影响报告.
结论:
- CT引导的腰部交友解剖显示出作为下肢耐火性CIPN的有效和安全的治疗选择的潜力.
- 该程序提供了大量的症状缓解,建议它作为一个可行的治疗策略.
- 通过更大规模的受控研究进行进一步验证是有必要的,以证实这些有前途的初步发现.
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