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Updated: Feb 24, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Published on: July 25, 2020

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向PFKFB3,以增强ER+乳腺癌中CDK4/6抑制剂的反应

Sucheta Telang, Brian F Clem, Ariamna A Herrera Miret

    Research square
    |February 23, 2026
    PubMed
    概括

    循环素依赖性激酶4和6 (CDK4/6) 抑制剂在ER阳性乳腺癌中增加糖解. 将CDK4/6抑制剂与PFKFB3抑制相结合,通过破坏代谢适应来增强抗瘤效应.

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