在西班牙裔社区的健康研究 / 拉丁裔的研究:一个生命过程模型分析
Research square
|February 23, 2026
概括
在整个生命中,心理社会逆境加快了生物衰老,特别是在成年期. 童年逆境也会影响衰老,不同的生命周期模型解释了对不同衰老标志物的影响.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 生命过程 流行病学 流行病学
背景情况:
- 整个生命周期的心理社会逆境可以影响衰老过程.
- 现有的生命过程模型不足以解释心理社会逆境在衰老中的生物嵌入.
- 了解这些途径对于公共卫生和临床干预至关重要.
研究的目的:
- 用表观遗传标记来评估心理社会逆境对生物衰老的影响.
- 确定最兼容的生命周期模型来解释逆境对衰老的影响.
- 评估童年与成人逆境对生物衰老的差异性贡献.
主要方法:
- 利用了来自西班牙裔社区健康研究/拉丁裔研究的亚样本 (N=970) 的DNA甲基化数据.
- 使用GrimAge和DunedinPACE指标估计的表观遗传年龄.
- 修改了贝叶斯生命周期模型来量化童年和成年时期的逆境影响,并测试了积累与敏感时期模型的对比.
- 采用因果调解分析来评估生命早期逆境的间接影响.
主要成果:
- 心理社会逆境的增加与加速的GrimAge (每单位增加0.91年,82%归因于成年期) 和DunedinPACE (每年0.013年,童年和成年期的贡献几乎相等) 相关.
- 童年逆境对GrimAge加速 (0.23年) 有显著的间接影响,但对DunedinPACE的影响很小.
- 这些发现表明,根据衰老标志物,积累和敏感期模型都可能是相关的.
结论:
- 从童年到成年期经历的心理社会逆境显著影响生物衰老标志物.
- 成年时期的逆境在加快青春期中起着更为重要的作用,而儿童时期的逆境则具有显著的间接影响.
- 需要不同的生命周期模型来充分阐明逆境和生物衰老之间的复杂关系.
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