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在新辅助免疫化学疗法后,头平细胞癌的手术最佳时间

Hanbo Seng¹, Yunli Fan², Rui Zhao²

¹Department of Otolaryngology Head and Neck surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in oncology

|February 23, 2026

概括

新辅助免疫化学疗法 (NAIC) 和手术治疗头部和部状细胞癌 (HNSCC) 之间的时间会影响结果. 在NAIC后延迟外科手术超过3周,与病理反应恶化和并发症增加有关.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
头部和部癌症研究研究

背景情况:

新辅助免疫化学疗法 (NAIC) 是治疗头部和部状细胞癌 (HNSCC) 的标准治疗方法.
在HNSCC患者中NAIC后手术的最佳时间仍在调查中.
了解NAIC手术间隔的影响对于优化治疗方案至关重要.

研究的目的:

评估NAIC和手术之间的时间间隔对HNSCC病理反应和手术结果的影响.
为了确定特定的手术时间 (TTS) 值是否会影响治疗疗效和患者存活率.

主要方法:

在NAIC后接受手术的356名HNSCC患者的回顾性分析.
根据在NAIC完成后的手术时间 (TTS) 来对患者进行分类.
评估结果包括主要病理反应 (mPR),病理完整反应 (pCR),手术并发症和3年无病生存期 (DFS).

主要成果:

总共分析了356名患者,63.2%的患者实现了mPR,29.2%的患者实现了pCR.
1-3周的TTS显示了可比的pCR和mPR率与1周以下的TTS.
超过3周的TTS与总瘤回归的可能性降低了16%,主要瘤回归的可能性降低了21%,手术并发症增加,复发或死亡风险更高.

结论:

在NAIC后超过3周的手术时间 (TTS) 独立地与HNSCC的病理反应 (pCR,mPR) 降低有关.
较长的间隔 (>3周) 与增加的手术并发症和减少无病生存时间有关.
在HNSCC中NAIC完成和手术之间的最佳间隔似乎在3周内,这证明了未来的验证.

关键词:

没有疾病的生存率.头部和部状细胞癌瘤新辅助免疫化学疗法新辅助免疫化学疗法病理反应的病理反应.手术并发症手术并发症到了手术的时间.

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