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相关概念视频

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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硫酸光固化异化物衍生网络:配方和3D打印

Dumitru Moraru1, Giacomo Trapasso2, Davide Dalla Torre2

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基于生物的新型乙烯光电复合物是从异化物衍生物制成的. 这些材料表现出高效的光聚合,调节性质和成功的3D打印应用.

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通过3D打印打印3D打印.紫外线治愈使用紫外线治愈生物基的基单体.它是异位吸收的.硫基因光聚合的光聚合.

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科学领域:

  • 聚合物科学 聚合物科学
  • 有机化学 有机化学
  • 材料科学 材料科学 材料科学

背景情况:

  • 生物基单体异化物为聚合物应用提供了刚性V形结构.
  • 越来越多的工业对异化物及其衍生物的兴趣,用于可持续材料.

研究的目的:

  • 从异索化物及其表皮物合成新型的硫烯光电复合物.
  • 为了研究光聚合行为和网络属性.
  • 探索表面修饰和3D打印能力.

主要方法:

  • 使用二甲基碳酸盐化学和1,5,7-triazabicyclo[4.4.0]-dec-5-ene (TBD) 催化剂制备异索化物,异曼化物和异化物的二甲基衍生物.
  • 使用三甲基烯三-(3-mercaptopropionate) 作为三功能醇的光聚合.
  • 通过实时里埃变换红外光谱学,差分扫描热度计 (DSC) 和动态机械热分析进行表征.
  • 用聚乙烯甘甲酸盐 (PEGMA) 和接触角测量进行表面修饰.
  • 使用数字光处理 (DLP) 进行3D打印.

主要成果:

  • 从异索化物衍生物中成功合成了新的生物基dialkyne单体.
  • 观察到高效的光聚合动力学和网络形成.
  • 可调节的材料特性和通过表面修改实现的增强水友性.
  • 精确的3D打印结构证明了优化的配方的可行性.

结论:

  • 新的基于生物的醇-烯光电复合物成功地从异类衍生物中制备出来.
  • 这些材料表现出有希望的光聚合特性和可调节性质.
  • 开发的光纤适用于先进的应用,如3D打印.