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清细胞细胞癌的复发经过切除术30年后呈现出新发的糖尿病
Alexander Ponce1, Victoria Comfort1, Samuel Peeples2
1Internal Medicine, William Carey University College of Osteopathic Medicine, Hattiesburg, USA.
Cureus
|February 23, 2026
概括
清细胞细胞癌 (ccRCC) 的罕见病例在腎切除术后33年复发,呈现为新发糖尿病和转移性胰腺质量. 这强调了在患有不明原因代谢变化的患者中考虑转移性ccRCC的重要性.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 医学案例报告 病例报告
背景情况:
- 清细胞细胞癌 (ccRCC) 是最常见的癌.
- 切除术后的复发并不常见,尤其是在几十年后.
- 新发型糖尿病很少被记录为转移性ccRCC的表现.
研究的目的:
- 报告ccRCC.晚期复发的一个独特案例.
- 强调ccRCC与新发糖尿病之间的关联.
- 突出考虑在患有不明原因代谢异常的患者中转移性疾病的重要性.
主要方法:
- 一个80岁的男性病例报告,有ccRCC的远程病史.
- 诊断工作包括实验室评估,计算机断层扫描,正子辐射断层扫描和活检.
- 治疗涉及使用阿克西替尼和潘布罗利祖马布进行全身治疗.
主要成果:
- 该患者出现了显著的体重减轻,疲劳和新发严重高血糖症 (A1C 13.7%).
- 图像检测显示胰腺质量与肺和肝脏的转移性病变,确认是转移性ccRCC.
- 系统治疗导致瘤负担减少和肺转移的解决.
结论:
- 这一案例说明了ccRCC复发的罕见情况,即切除术后33年.
- 无法解释的代谢异常,如新发糖尿病,可能是转移性ccRCC的预兆.
- 转移性ccRCC应考虑在患有远程细胞癌史和新的代谢障碍的患者.
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