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的毒性:一项系统性审查和与非对照研究的元分析,针对有情绪障碍的患者进行
Marie Michele Macaron1,2, Mireilla Abou Rjeily3, Raphael Macaron4
1School of Medicine, St. George's University of London, London, UK.
Therapeutic advances in psychopharmacology
|February 23, 2026
概括
对双相情感障碍的治疗可能会对功能产生负面影响,以较低的估计膜过率 (eGFR) 表示. 定期监测脏健康对于长期使用治疗的患者至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 是双相情感障碍 (BD) 的首要治疗方法.
- 在长期使用者中,人们对诱导的脏病存在担忧.
- 与BD相关的混因素对功能的影响尚未完全理解.
研究的目的:
- 为了评估在治疗中患有情感障碍的患者的功能,与没有治疗的患者相比.
- 进行现有研究的系统审查和元分析.
主要方法:
- 在多个数据库 (Cochrane,Embase,PubMed,Scopus,Web of Science,CINAHL) 进行全面的文献搜索,截至2023年10月.
- 包括观察性研究,比较成年情感障碍患者的与非的对照,评估功能结果.
- 使用ROBINS-E工具进行偏差风险评估.
主要成果:
- 与非使用者相比,使用者显示出较低的平均估计球过率 (eGFR) (MD = -11.14毫升/分钟/1.73米2).
- 在非组 (MD = 0.13 ml/min/1.73 m2) 中,每年eGFR的下降更为有利.
- 在组中观察到较高的血清肌素水平;然而,在新的或进展的慢性病事件中没有发现统计学上显著的差异. 发现了很高的异质性.
结论:
- 通过eGFR评估的功能,与不服用的患者相比,服用的患者的功能下降.
- 持续监测功能和风险-益处讨论对于患者至关重要,特别是那些有先前存在的问题的人.
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