自由脂肪酸与糖尿病患者和没有糖尿病患者进行皮肤冠状动脉干预的不良结果之间的关联
Qinxue Li1, Guyu Zeng2, Deshan Yuan2
1Department of Cardiology, Xuanwu Hospital, Capital Medical University, National Clinical Research Centre for Geriatric Diseases, Beijing, China.
Journal of translational internal medicine
|February 23, 2026
概括
自由脂肪酸 (FFA) 水平会影响经皮冠状动脉干预 (PCI) 接受糖尿病患者的主要不良心血管和脑血管事件 (MACCE). 高和低的FFA水平都会增加MACCE风险,突出显示需要监测.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 干预心脏病学 干预心脏病学
背景情况:
- 自由脂肪酸 (FFA) 水平与心血管疾病有关.
- 穿皮冠状动脉干预 (PCI) 后的FFA水平和结果之间的关系尚未完全理解,特别是在糖尿病患者中.
研究的目的:
- 在接受PCI的患者中,研究自由脂肪酸 (FFA) 水平与主要心血管和脑血管不良事件 (MACCE) 之间的关联.
- 为了确定糖尿病是否会改变这种关联.
主要方法:
- 一组10230名接受PCI的患者被分为低,中和高FFA组.
- 根据糖尿病状况对患者进行了分层分类,并对MACCE进行了5年的随访.
- 使用了统计分析,包括调整的危险比率和限制的立方线.
主要成果:
- 在非糖尿病患者中,没有发现FFA水平和MACCE之间的显著关联.
- 在糖尿病患者中,低 (FFA-L) 和高 (FFA-H) 的FFA水平与与中等FFA组 (FFA-M) 相比显著增加MACCE风险有关.
- 在糖尿病患者中观察到FFA水平和MACCE风险之间存在非线性U形关系,风险最低为372μmol/L.
结论:
- 在接受PCI的糖尿病患者中,低和高的自由脂肪酸 (FFA) 水平与较高的重大心血管和脑血管不良事件 (MACCE) 风险有关.
- 监测FFA水平可以帮助识别接受PCI的高风险糖尿病患者.
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