MetALD:解读肥胖性肝病命名体系的演变及其对临床实践及其他领域的影响
Farinaz Ghodrati1, Ashley B Zhang1, Nadim Mahmud2,3,4,5
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与代谢功能障碍相关的脂肪性肝炎 (MASH) 等新术语改善了脂肪性肝病 (SLD) 的分类. 新的代谢和与酒精有关的肝病 (MetALD) 亚分类有助于诊断和护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 肝脏疾病分类 肝脏疾病分类
背景情况:
- 脂肪性肝病 (SLD) 景观由于多社会德尔菲共识而发生了重大变化.
- 以前的术语面临着污名化和模两可的术语的挑战.
- 由于SLD的全球流行率越来越高,因此需要准确的分类.
研究的目的:
- 讨论最近SLD命名法变化的催化剂.
- 探索SLD亚类的动态性质,包括新型代谢和酒精相关性肝病 (MetALD).
- 审查对临床实践和研究的影响,重点关注MetALD.
主要方法:
- 审查最近的多社会德尔菲关于肝病命名的共识.
- 从较旧的术语过渡到与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与代谢功能障碍相关的脂肪性肝炎 (MASH) 的分析.
- 检查新分类MetALD.的诊断标准和临床影响.
主要成果:
- 引入MASLD和MASH解决了先前术语的局限性,强调了潜在的风险因素.
- 代谢性和与酒精有关的肝病 (MetALD) 的新型分类提供了一个独特的临床实体.
- 这种命名体系的转变提高了意识,并促进了有针对性的治疗和多学科管理.
结论:
- 更新后的命名法,包括MASLD,MASH和MetALD,提供了更清晰的诊断标准,并强调了潜在的代谢驱动因素.
- 承认MetALD作为一个独特的实体,可以改善患有重叠心脏代谢和酒精相关肝脏疾病的患者的护理.
- 这些变化对于在脂肪性肝病领域推进临床实践和研究至关重要.
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