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评估用于输血的带血的质量参数
Madhavi Ambhore1, Dibyajyoti Sahoo1, T Chitra2
1Department of Transfusion Medicine, JIPMER (Jawaharlal Institute of Postgraduate Medical Education and Research), Puducherry, India.
概括
带血 (UCB) 质量被评估为输血安全. 结果显示,UCB与成年人的血液相似,这表明它可以在收集后不久安全地输血.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 生物医学科学 生物医学科学
背景情况:
- 使用带血 (UCB) 进行血造干细胞移植对于治疗血液学疾病至关重要.
- 目前,大量的UCB被作为生物废物丢弃.
- 对输血UCB产品安全性的担忧限制了它们更广泛的应用.
研究的目的:
- 评估UCB的质量参数,以确保其对人体输血的安全性.
- 为了比较UCB的质量与成年人全血的输血适用性.
主要方法:
- 在印度南部进行了一项前性观察研究.
- 质量评估包括体积,凝块存在,血液溶解,血血红蛋白,水平,完整血清和不孕测试.
- 在存储时间内监测UCB单位.
主要成果:
- 最初,UCB没有显示出血解和正常的水平,与成人血液相比.
- 随着储存时间的推移,观察到和血血红蛋白水平的显著增加 (p < 0.05).
- 所有UCB单元即使在培养14天后仍然是无菌的.
结论:
- 统一的UCB单位显示的质量参数与成年人的血液相美.
- 在采集后不久,可以考虑输血UCB,只要满足质量检查.
- 这一发现支持将废弃的UCB用于输血目的的潜在利用.
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