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阴性HPV的基质状细胞直肠癌:一个非常罕见的实体

Idan Grossmann¹, Harshavardhan Sanekommu², Sidra Ahsan²

¹Department of Internal Medicine, Jersey Shore University Medical Center, Neptune, NJ.

ACG case reports journal

|February 23, 2026

概括

结直肠的基底状状细胞癌 (BSCC) 是非常罕见的. 这一案例突出了诊断挑战,并揭示了这种罕见的直肠癌患者的高瘤突变负担和PD-L1表达.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

基底状状细胞癌 (BSCC) 是一种罕见的直肠恶性瘤.
人类乳头瘤病毒 (HPV) 与直肠BSCC的相关性尚未得到充分证实.
结直肠癌常常伴有诸如疲劳和血等非特异性症状.

研究的目的:

报告一个非常罕见的基底状状细胞癌直肠病例.
为了调查人类乳头瘤病毒 (HPV) 在直肠BSCC.状态.
描述直肠BSCC的分子概况,包括瘤突变负担和PD-L1表达.

主要方法:

一个66岁的妇女的病例报告与直肠质量.
诊断性结肠镜检查和活检.
针对HPV的免疫组织化学.
对瘤突变负担和PD-L1表达的分子分析.

主要成果:

活检证实了直肠的差异化基底状状细胞癌 (BSCC).
针对HPV的免疫组织化学反应是负的.
分子分析揭示了高瘤突变负担和升高的PD-L1表达.

结论:

直肠基底状状细胞癌 (BSCC) 是一种极其罕见的实体.
这一案例突出了与直肠BSCC相关的诊断和治疗挑战.
分子形状,包括高瘤突变负担和PD-L1表达,可能对罕见直肠癌的未来治疗策略产生影响.

关键词:

这是一个HPVHPVHPV.门基底状状细胞癌瘤这是直肠癌.

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