加快的DMN向cTBS改善了精神分裂症的处理速度缺陷.
medRxiv : the preprint server for health sciences
|February 23, 2026
概括
针对默认模式网络 (DMN) 的跨磁刺激 (TMS) 改善了精神分裂症患者的处理速度. 减少DMN连接与认知收益相关,特别是在年轻人中.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症的特点是显著的认知缺陷,影响日常功能.
- 信息处理速度受损是精神分裂症的一个核心认知缺陷.
- 正在调查这些缺陷的神经支,特别是默认模式网络 (DMN) 的超连接性.
研究的目的:
- 调查针对DMN的跨磁刺激 (TMS) 是否可以提高精神分裂症患者的处理速度.
- 探索DMN连接调制和处理速度改进之间的关系.
- 评估年龄对治疗反应的影响.
主要方法:
- 进行了两项研究:单次会议TMS (iTBS,cTBS,假) 和多次会议加速cTBS.
- 参与者包括精神分裂症患者和非精神病控制者.
- 在TMS干预之前和之后进行了休息状态神经影像和处理速度评估 (数字符号编码).
主要成果:
- 多会话DMN向cTBS显著改善了精神分裂症组的处理速度 (p=0.0124).
- 减少DMN连接性与精神分裂症患者的处理速度提高有关 (p=0.021).
- 年轻的参与者与老年参与者相比,处理速度得到了更大的改善 (p=0.006).
结论:
- 个性化,网络向的TMS为精神分裂症认知障碍提供了一种新的治疗方法.
- 通过TMS调节DMN连接显示出治疗处理速度缺陷的希望.
- 年龄是影响DMN向TMS用于认知增强功能的重要因素.
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