Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K
Longitudinal Research02:20

Longitudinal Research

13.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.5K
Longitudinal Studies01:26

Longitudinal Studies

563
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
563
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.0K
Aging01:26

Aging

889
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
889
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Relaxometry and diffusion MRI reveal sex differences in the association between daytime sleepiness and white matter myelination.

Sleep advances : a journal of the Sleep Research Society·2026
Same author

Alpha-klotho, insulin resistance, and adiposity among older adults.

Journal of the Endocrine Society·2026
Same author

Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.

Stroke·2026
Same author

Immune aging biomarkers for clinical trials.

Nature medicine·2026
Same author

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same author

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

Neurology·2026

相关实验视频

Updated: Feb 24, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K

循环细胞类型衰老特征揭示了人类纵向研究中的高分辨率健康状况和轨迹.

Bradley Olinger, Carlos Anerillas, Allison B Herman

    medRxiv : the preprint server for health sciences
    |February 23, 2026
    PubMed
    概括

    循环中的细胞衰老生物标志物可以预测健康状况和疾病风险. 细胞类型特定的衰老特征提供了对衰老和健康轨迹的更高分辨率洞察力.

    更多相关视频

    Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
    08:56

    Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

    Published on: July 12, 2022

    3.6K
    Techniques to Induce and Quantify Cellular Senescence
    06:51

    Techniques to Induce and Quantify Cellular Senescence

    Published on: May 1, 2017

    35.3K

    相关实验视频

    Last Updated: Feb 24, 2026

    Induction and Validation of Cellular Senescence in Primary Human Cells
    08:18

    Induction and Validation of Cellular Senescence in Primary Human Cells

    Published on: June 20, 2018

    18.1K
    Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
    08:56

    Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

    Published on: July 12, 2022

    3.6K
    Techniques to Induce and Quantify Cellular Senescence
    06:51

    Techniques to Induce and Quantify Cellular Senescence

    Published on: May 1, 2017

    35.3K

    科学领域:

    • 生物标志物 生物标志物
    • 衰老研究研究 衰老研究
    • 细胞生物学 细胞生物学

    背景情况:

    • 细胞衰老随着年龄的增长而增加,并导致与年龄相关的疾病.
    • 循环的衰老特征可以预测与年龄相关的特征和疾病.
    • 细胞类型特定的衰老特征尚未完全探索.

    研究的目的:

    • 检查循环中的细胞类型特定衰老特征的临床相关性.
    • 确定衰老特征是否可以预测临床参数和疾病发病.
    • 评估循环衰老生物标志物的诊断潜力.

    主要方法:

    • 在14种人类细胞类型中利用了来自老化目录 (SenCat) 的老化签名.
    • 分析了来自两个纵向研究的数据:巴尔的摩老龄化纵向研究 (BLSA) 和Invecchiare in Chianti (InCHIANTI) 研究.
    • 对比了聚合和细胞类型特定的衰老蛋白与非衰老蛋白的预测性能.

    主要成果:

    • 聚合的衰老蛋白在预测年龄和高血压等临床参数方面优于非衰老蛋白.
    • 细胞类型的衰老特征经常被强烈地映射到它们相应的健康领域.
    • 免疫细胞衰老的特征与未来出现的糖尿病等疾病有关.

    结论:

    • 循环中的与衰老相关的蛋白质作为临床表型的有效生物标志物.
    • 一个核心衰老特征预测了整个衰老过程中的各种临床表型.
    • 细胞类型特定的衰老特征提供了更高分辨率的健康状况洞察力,并与评估健康轨迹,包括死亡率和疾病发病相关.