人类和病毒全基因组测序确定HPV和APOBEC是鼻状细胞癌的致癌驱动因素
medRxiv : the preprint server for health sciences
|February 23, 2026
概括
人类乳头瘤病毒 (HPV) 驱动着鼻腔状细胞癌 (SNSCC) 的进化,特别是通过较少研究的菌株. 了解这些HPV与人类的相互作用对于推进SNSCC诊断和治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 鼻腔状细胞癌 (SNSCC) 是一种具有侵略性的头癌,治疗进展有限.
- 虽然在历史上与环境因素有关,但SNSCC显示与人类乳头瘤病毒 (HPV) 的偶然关联.
- HPV 是口腔癌的已知驱动因素,但其在SNSCC中的作用尚未完全理解.
研究的目的:
- 为了调查SNSCC中的HPV的基因组足迹.
- 为了识别参与SNSCC瘤发生的特定HPV菌株.
- 阐明SNSCC瘤进化的宿主病毒相互作用的机制.
主要方法:
- 配对宿主和SNSCC瘤的病毒全基因组测序 (WGS).
- 对病毒整合模式和宿主基因组变化的分析.
- 鉴定特定的HPV菌株及其与染色体外DNA (ecDNA) 的关联.
主要成果:
- 证实HPV是SNSCC的主要致癌驱动因素.
- 较少研究的HPV菌株 (例如,HPV45,51,39) 被确定为司机感染.
- HPV融入ecDNA和APOBEC突变发生是瘤进化的关键机制.
结论:
- 包括非正规菌株在内的HPV在SNSCC致癌过程中起着重要作用.
- 在SNSCC中,HPV-人类ecDNA安普利康是病毒瘤发生的关键调解者.
- 目前的HPV诊断面板应该扩大,包括较少研究的菌株,以全面检测SNSCC.
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