为秘鲁成年人开发和验证基于回归的神经心理测试标准,以检测与艾滋病毒相关的神经认知障碍
medRxiv : the preprint server for health sciences
|February 23, 2026
概括
在秘鲁,当地开发的神经心理学规范改善了艾滋病毒感染者神经认知障碍的诊断. 与国际标准相比,这些新的西班牙规范更好地检测认知变化.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 神经认知障碍 (NCI) 在艾滋病毒感染者 (PWH) 中普遍存在,特别是在资源有限的环境中.
- 与艾滋病毒相关的NCI的准确诊断受到西班牙语局部验证的神经心理 (NP) 规范数据的缺乏所阻碍.
- 这在秘鲁尤为关键,因为PWH可能在较年轻的年龄发展为NCI.
研究的目的:
- 为秘鲁利马的年轻和中年西班牙语成年人开发基于回归的NP规范.
- 在人口统计学上类似的PWH中验证这些规范,以提高与艾滋病毒相关的NCI的诊断精度.
主要方法:
- 利马的164名健康成年人完成了全面的NP电池.
- 多重回归模型被用来建立基于年龄,教育和性别的人口调整规范.
- 开发的标准适用于310 PWH,并与之前发布的西班牙标准进行了比较.
主要成果:
- 年龄和教育显著预测了NP测试的表现;性别的影响最小.
- 与对照组相比,PWH在几个NP测试中表现明显较低,教育程度较低,表现更差.
- 与以前发布的规范相比,特定人口的规范揭示了T-score的显著差异,表明非本地数据的潜在诊断错误.
结论:
- 在秘鲁,局部衍生的NP规范对于检测秘鲁PWH的微妙认知变化至关重要.
- 使用这些规范可以更好地检测不同组之间的差异,这些差异可能会被非本地数据遗漏.
- 未来的研究应该将规范发展扩展到农村地区,并包括拉丁美洲教育背景较低的个人.
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