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三种系统性炎症生物标志物与糖尿病足之间的关联:一项截面研究和一项临床回顾性研究

Hua Chen¹, Yu Zhou², Jiezhi Dai¹

¹Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, JiaoTong University, Shanghai, China, sjtu.edu.cn.

Mediators of inflammation

|February 23, 2026

概括

系统性炎症标志物升高,包括系统性炎症反应指数 (SIRI),系统性免疫炎症指数 (SII) 和系统性炎症总指数 (AISI),与糖尿病足 (DFU) 的更高患病率显著相关. 这些生物标志物可能有助于DFU风险评估.

科学领域:

生物医学研究的研究.
临床诊断临床诊断临床诊断
炎症研究的研究.

背景情况:

糖尿病足 (DFU) 是糖尿病的一个重要并发症.
系统性炎症生物标志物越来越多地被认为是它们在各种疾病中的作用.
特定炎症指数与DFU患病率之间的关联需要进一步调查.

研究的目的:

调查系统性炎症反应指数 (SIRI),系统性免疫炎症指数 (SII) 和系统性炎症总指数 (AISI) 与糖尿病足 (DFU) 的患病率之间的关联.

主要方法:

对NHANES数据 (31,126名参与者) 和一项回顾性临床研究 (34名DFU患者,68名对照) 的横截面分析.
后勤回归和受限立方线 (RCS) 分析被用来评估炎症指数和DFU之间的关联.
进行了子组分析和接收器运行特征 (ROC) 曲线分析,以验证和评估歧视能力.

主要成果:

在NHANES和临床队列中,SIRI,SII,AISI和DFU流行率之间发现了一致的积极关联.
在所有三种生物标志物中都观察到线性剂量反应关系.
与SIRI和AISI相比,系统性免疫炎症指数 (SII) 在预测DFU方面表现出更高的区分能力.

结论:

高水平的SIRI,SII和AISI与增加的DFU患病率显著相关.
这些系统性炎症生物标志物显示出作为DFU风险分层的有价值工具的潜力.
进一步的研究可以探索这些指数在治疗糖尿病患者中的临床实用性.

关键词:

美国 DFU DFU 尼汉斯 (NHANES) 是一个名人.系统性炎症的综合指数.这是一项回顾性研究.免疫系统炎症指数系统性炎症反应指数

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