尽管在类风湿性关节炎中炎症活性较低,但对持续性疼痛的干预措施:系统性审查
Ryuichi Ohta1, Taichi Fujimori1, Kunihiro Ichinose2
1Community Care, Unnan City Hospital, Unnan, JPN.
Cureus
|February 23, 2026
概括
尽管可以控制炎症,但类风湿性关节炎 (RA) 中持续的疼痛是具有挑战性的. 运动和生活方式的改变比针对炎症的药物对 RA 患者的疼痛缓解更有希望.
科学领域:
- 类风湿病学 类风湿病学
- 疼痛管理 疼痛管理
- 临床研究 临床研究
背景情况:
- 在类风湿性关节炎 (RA) 中,持续的疼痛通常会继续存在,尽管可以控制炎症活动.
- 这表明疼痛机制超出了活跃的突炎,需要对有效干预措施进行调查.
研究的目的:
- 系统地审查药理和非药理干预措施,以控制炎症的RA患者的持续疼痛.
- 综合这些干预措施在减少疼痛和改善功能方面有效性的证据.
主要方法:
- 随机对照试验,后期分析和前性观察研究的系统审查.
- 搜索了主要的生物医学数据库,寻找报告成人RA患者疼痛相关结果的研究.
- 由于研究设计和结果的异质性,叙事综合.
主要成果:
- 药理干预 (DMARDs,生物药物,JAK抑制剂) 显示出有限而异质的疼痛缓解.
- 非药物治疗方法,特别是运动和物理治疗,证明了独立于炎症的持续性疼痛减轻.
- 像omega-3脂肪酸这样的生活方式因素也可能影响疼痛的结果.
结论:
- 针对炎症的治疗方法为持续的RA疼痛提供了部分缓解.
- 将基于炼和生活方式的策略与药物治疗相结合,对于 RA 综合性疼痛管理至关重要.
- 需要基于机制的方法来治疗控制炎症的RA患者的持续疼痛.
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