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Updated: Feb 24, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
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通过激活 EPAC-RAP1A 信号轴,ESRP1 驱动了表皮细胞-介质细胞过渡

Ruixin Qi1, Jiaqi Wang1, Guocang Cheng2

  • 1Ningxia Key Laboratory of Clinical and Pathogenic Microorganisms, Institute of Medical Science, General Hospital of Ningxia Medical University, Yinchuan, China.

Frontiers in medicine
|February 23, 2026
PubMed
概括

表皮剪接调节蛋白1 (ESRP1) 的上调促进异常性肺纤维化 (IPF),通过驱动表皮-介质细胞过渡 (EMT). 这通过Epac-Rap1a信号通路发生,突出显示ESRP1是IPF的潜在治疗标.

关键词:
在 Epac-Rap1a 信号传输中.皮质上皮质上皮质上皮质.表皮拼接调节蛋白1 (ESRP1) 是一种表皮拼接调节蛋白.表皮细胞-介质细胞过渡 (EMT)异形性肺纤维化 异形性肺纤维化单细胞RNA测序 (scRNA-seq) 是一种

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