相关实验视频

Updated: Feb 24, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

抗生素DB:一个更新和改进的开放访问数据库,用于抗菌研究和开发社区

Luiza H Galarion¹, Alan Hennessy², Simon D Harding³

¹Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K.

ACS infectious diseases

|February 23, 2026

概括

抗菌剂的数据库AntibioticDB已经更新,增加了新的功能和内容. 这个资源现在包括超过3,500条条目,增强新抗生素治疗药物的研究.

科学领域:

* 药理学和药物化学
* 化学信息学和生物信息学

背景情况:

*抗生素数据库 (AntibioticDB) 是一个免费访问的抗菌剂数据库,成立于2017年,自2021年以来由全球抗生素研发伙伴关系 (GARDP) 领导.
*该数据库旨在支持和加速新型抗菌疗法的研究和开发.
* 之前的版本需要改进,以更好地服务于科学界.

研究的目的:

* 宣布和描述AntibioticDB数据库的最新版本.
*以突出显著的扩展,更新的功能和改进的数据集成.
*强调数据库作为抗菌剂的全面全球资源的作用.

主要方法:

*重新设计的网页门户,增强了用户功能.
* 相互整合与IUPHAR/BPS药理学指南.
* 纳入标准化学标识符 (SMILES,InChI,InChI Key) 和2D结构图像.
* 对术语进行协调,以优化数据库搜索.
* 持续的文献挖掘和数据策划,寻找新的抗菌化合物.

主要成果:

* 抗生素数据库现在有超过3,500条条目,与以前的版本相比显著扩展.
* 历史性天然产品抗生素的大量增加已被纳入.
* 增强的数据捕获包括化学结构和标识符,提高了数据的实用性.
*数据库不断更新,以新报告的抗菌化合物.

结论:

*更新后的抗生素数据库为研究人员提供了更全面,更易于使用的资源.
*其扩展的内容,特别是天然产品抗生素,以及改进的数据整合,有助于药物发现.
*抗生素DB巩固了其作为抗菌剂最完整的全球资源的地位.

关键词:

抗生素DBDB 的它是一种抗菌药物,具有抗菌作用.抗生素抗生素是一种抗生素.化学化学化学化学化学化学化学我们的数据库数据库数据库数据库.结构结构结构结构

更多相关视频

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Published on: May 15, 2019

相关概念视频

Antibiotic Selection

Antibiotic Selection

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...